منابع مشابه
CaMKII Mediates Digitalis - Induced Arrhythmias
Background Digitalis-induced Na accumulation results in an increase in Cai via the Na/Ca exchanger leading to enhanced SR Ca load, responsible for the positive inotropic and toxic arrhythmogenic effects of glycosides. Digitalis-induced increase in Cai could also activate CaMKII which has been shown to have proarrhythmic effects. Here we investigate whether CaMKII underlies digitalis-induced arr...
متن کاملCaMKII Mediates Digitalis - Induced Arrhythmias Running title :
Background Digitalis-induced Na accumulation results in an increase in Cai via the Na/Ca exchanger leading to enhanced SR Ca load, responsible for the positive inotropic and toxic arrhythmogenic effects of glycosides. Digitalis-induced increase in Cai could also activate CaMKII which has been shown to have proarrhythmic effects. Here we investigate whether CaMKII underlies digitalis-induced arr...
متن کاملCalcium-calmodulin kinase II mediates digitalis-induced arrhythmias.
BACKGROUND Digitalis-induced Na(+) accumulation results in an increase in Ca(2+)(i) via the Na(+)/Ca(2+) exchanger, leading to enhanced sarcoplasmic reticulum (SR) Ca(2+) load, responsible for the positive inotropic and toxic arrhythmogenic effects of glycosides. A digitalis-induced increase in Ca(2+)(i) could also activate calcium-calmodulin kinase II (CaMKII), which has been shown to have pro...
متن کاملMagnesium's Mechanism of Action in Digitalis-induced Arrhythmias
The mechanism by which magnesium affects digitalis-induced arrhythmias was studied in dogs with and without beta-receptor blockade. Digoxin was infused at a rate of 2.5,ug/kg/min until ventricular tachycardia developed, then half the animals were given MgSO4, the other half saline. In animals given MgSO4, sinus rhythm was immediately re-established; in animals given saline, ventricular tachycar...
متن کاملStudies on magnesium's mechanism of action in digitalis-induced arrhythmias.
The mechanism by which magnesium affects digitalis-induced arrhythmias was studied in dogs with and without beta-receptor blockade. Digoxin was infused at a rate of 2.5mug/kg/min until ventricular tachycardia developed, then half the animals were given MgSO4, the other half saline. In animals given MgSO4, sinus rhythm was immediately re-established; in animals given saline, ventricular tachycar...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 1969
ISSN: 0021-4868,1348-673X
DOI: 10.1536/ihj.10.409